What is the ACE2 receptor, how is it connected to coronavirus and why might it be key to treating COVID-19? The experts explain
SARS-CoV-2 Infection & Cardiology: Overview on Renin-Angiotensin-Aldosterone System Inhibition
Angiotensin-converting enzyme 2 - Wikipedia
Allosteric Site of ACE-2 as a Drug Target for COVID-19 | ACS Pharmacology & Translational Science
Soluble angiotensin‐converting enzyme 2 is transiently elevated in COVID‐19 and correlates with specific inflammatory and endothelial markers - Lundström - 2021 - Journal of Medical Virology - Wiley Online Library
IJMS | Free Full-Text | Characterization of ACE and ACE2 Expression within Different Organs of the NOD Mouse
Angiotensin-konvertierendes Enzym aus Kaninchenlunge ≥2.0 units/mg protein (modified Warburg-Christian) | Sigma-Aldrich
Downregulation of ACE2 induces overstimulation of the renin–angiotensin system in COVID-19: should we block the renin–angiotensin system? | Hypertension Research
Do Studies With ACE N- and C-Domain–Selective Inhibitors Provide Evidence for a Non-ACE, Non-Chymase Angiotensin II–Forming Pathway? | Circulation Research
Selective Inhibition of the C-Domain of ACE (Angiotensin-Converting Enzyme) Combined With Inhibition of NEP (Neprilysin): A Potential New Therapy for Hypertension | Hypertension
Dysregulation of ACE (Angiotensin-Converting Enzyme)-2 and Renin-Angiotensin Peptides in SARS-CoV-2 Mediated Mortality and End-Organ Injuries | Hypertension
ACE inhibitors
What Is an Angiotensin Converting Enzyme Inhibitor? | Circulation
Angiotensin I-Converting Enzyme (ACE) Inhibitory and Antioxidant Activity of Umami Peptides after In Vitro Gastrointestinal Digestion | Journal of Agricultural and Food Chemistry
An ACE structure | Nature Structural & Molecular Biology
SARS-CoV-2 pandemic and research gaps: Understanding SARS-CoV-2 interaction with the ACE2 receptor and implications for therapy
Structural and molecular basis of angiotensin-converting enzyme by computational modeling: Insights into the mechanisms of different inhibitors | PLOS ONE
IJMS | Free Full-Text | Two Opposing Functions of Angiotensin-Converting Enzyme (ACE) That Links Hypertension, Dementia, and Aging
Decrease in Angiotensin-Converting Enzyme activity but not concentration in plasma/lungs in COVID-19 patients offers clues for diagnosis/treatment: Molecular Therapy - Methods & Clinical Development
Figure 1 | Focus on Brain Angiotensin III and Aminopeptidase A in the Control of Hypertension
Renin-angiotensin system | Definition & Facts | Britannica
Molecules in pathogenesis: angiotensin converting enzyme 2 (ACE2) | Journal of Clinical Pathology
Drug-drug Interactions of Angiotensin Converting Enzyme Inhibitors Mediated by Metabolizing Enzymes and Transporters | Bentham Science